4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane
4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane
CAS: 872038-32-9
Molecular Formula: C14H18BF3O3
4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane - Names and Identifiers
| Name | 4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane |
| Synonyms | 4-(Trifluoromethoxy)phenylmethylboronic acid, pinacol ester 4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-[[4-(trifluoromethoxy)phenyl]methyl]- |
| CAS | 872038-32-9 |
| InChI | InChI=1/C14H18BF3O3/c1-12(2)13(3,4)21-15(20-12)9-10-5-7-11(8-6-10)19-14(16,17)18/h5-8H,9H2,1-4H3 |
4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane - Physico-chemical Properties
| Molecular Formula | C14H18BF3O3 |
| Molar Mass | 302.1 |
| Density | 1.139g/mLat 25°C |
| Boling Point | 100°C/0.2mmHg |
| Flash Point | 105°C |
| Vapor Presure | 0.00453mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.458 |
4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane - Risk and Safety
| WGK Germany | 3 |
4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane - Introduction
4,4, 5,5-tetraethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane is an organic compound with the formula C14H16BF3O3. The following is a description of some properties, uses, preparation and safety information about the compound:
Nature:
-Appearance: colorless liquid
-Boiling point: about 130-135°C
-Density: about 1.24g/cm³
-Melting point: about -25°C
-Solubility: Soluble in common organic solvents such as ethers and ketones
Use:
- 4,4, 5,5-tetrathyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane is an important intermediate in organic synthesis, which is commonly used to catalyze cross-coupling reactions, such as Suzuki reaction and ternary coupling reaction.
-It can also be used as a reagent and catalyst in organic synthesis, usually used to synthesize compounds containing aromatic groups and carbon-oxygen bonds.
-The compound also has potential applications in the field of medicine, such as fluorescent dyes, heterocyclic synthesis, and synthesis of anti-tumor and antiviral drugs.
Preparation Method:
- 4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane is prepared by a complicated method. Generally, benzylboronic acid pinacol ester reacts with trifluoromethanol, and the target product is obtained through a multi-step reaction.
Safety Information:
- 4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane for specific hazards and safety measures need to refer to the label and safety instructions on the chemical packaging.
-When using and handling this compound, wear suitable protective equipment, such as chemical protective gloves and protective glasses, and avoid contact with skin and eyes.
-In addition, it should be used in a well-ventilated place and follow the prescribed handling and storage methods. In the event of any negative reaction or accident, immediately take appropriate emergency measures and seek professional medical help.
Nature:
-Appearance: colorless liquid
-Boiling point: about 130-135°C
-Density: about 1.24g/cm³
-Melting point: about -25°C
-Solubility: Soluble in common organic solvents such as ethers and ketones
Use:
- 4,4, 5,5-tetrathyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane is an important intermediate in organic synthesis, which is commonly used to catalyze cross-coupling reactions, such as Suzuki reaction and ternary coupling reaction.
-It can also be used as a reagent and catalyst in organic synthesis, usually used to synthesize compounds containing aromatic groups and carbon-oxygen bonds.
-The compound also has potential applications in the field of medicine, such as fluorescent dyes, heterocyclic synthesis, and synthesis of anti-tumor and antiviral drugs.
Preparation Method:
- 4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane is prepared by a complicated method. Generally, benzylboronic acid pinacol ester reacts with trifluoromethanol, and the target product is obtained through a multi-step reaction.
Safety Information:
- 4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane for specific hazards and safety measures need to refer to the label and safety instructions on the chemical packaging.
-When using and handling this compound, wear suitable protective equipment, such as chemical protective gloves and protective glasses, and avoid contact with skin and eyes.
-In addition, it should be used in a well-ventilated place and follow the prescribed handling and storage methods. In the event of any negative reaction or accident, immediately take appropriate emergency measures and seek professional medical help.
Last Update：2024-04-09 20:52:54
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Product Name: 4-(TRIFLUOROMETHOXY)BENZYLBORONIC ACID & Visit Supplier Webpage Request for quotation
CAS: 872038-32-9
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Mobile: 18021002903
QQ: 3008007409
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CAS: 872038-32-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane
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